Paul Harrison is Professor of Psychiatry and Associate Head of Department (Research) at the Department of Psychiatry, Medical Sciences Division, University of Oxford, Warneford Hospital, Oxford, UK. Philip Cowen is Professor of Psychopharmacology at the Department of Psychiatry, Medical Sciences Division, University of Oxford, Warneford Hospital, Oxford, UK Mina Fazel is Professor (Chair) of Child & Adolescent Psychiatry at the Department of Psychiatry, Medical Sciences Division, University of Oxford, Warneford Hospital, Oxford, UK Kamaldeep Bhui is Professor of Psychiatry & Hon. Consultant Psychiatrist at the Department of Psychiatry, Medical Sciences Division, University of Oxford, Warneford Hospital, Oxford, UK